Kok, Y.P (2014) What is diurnal mood variation. Bachelor's Thesis, Biology.
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Abstract
Diurnal mood variation (DMV) is the change in mood over the course of the day, which is a characteristic in many depressed patients. There are two distinct forms of DMV, the classical form, with worse mood in the morning and an improvement towards the evening, and the reversed form, with a worsening of mood towards the evening. DMV is not just a response to environmental or behavioral conditions. Mood also follows an endogenous circadian rhythm. The lowest point in mood is observed during the night. DMV has been linked to a positive response to sleep deprivation. An explanation of why patients with DMV respond better to sleep deprivation has not yet emerged. Years of research have sought for an explanation what causes DMV. According to hypotheses that have been stated, DMV in depression can be understood from a weakened circadian function, or DMV is caused by increased susceptibility to stimuli. Patients who are more susceptible to stimuli tend to vary more in mood and have a higher chance of showing DMV. All these hypotheses treat the state of mood as a kind of black box. Specific regulatory relationships between brain areas and mood are not included in these studies. The direction of DMV seemed to be influenced by serotonin. Patients with a polymorphism in the promoter region of a serotonin transporter showed more reversed DMV than patients with classical DMV. Imaging studies showed that the balance between dorsal and ventral emotion neural systems is disrupted in DMV. In depressed patients, improvement of mood towards the evening is parallel with an increased metabolic activity in ventral limbic-paralimbic regions. These findings support the hypothesis, that limbic-paralimbic regions are involved in DMV. Further research is necessary to explain the exact mechanism underlying DMV. This knowledge is perhaps useful in designing personalized treatments for depression.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 15 Feb 2018 07:57 |
| Last Modified: | 15 Feb 2018 07:57 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/11721 |
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