Therapeutic potential of H2S and neurodegenerative diseases

Janszen, R. P. (2014) Therapeutic potential of H2S and neurodegenerative diseases. Bachelor's Thesis, Biology.

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Abstract

Neurodegenerative diseases including Alzheimer’s disease (AD) and Parkinson’s disease (PD) are growing in occurrence due to their age-related onset and a global increase in life expectancy. To prevent growing worldwide costs in healthcare, it is important to find therapeutic targets. Despite the differences in pathogenic onset, neurodegenerative diseases share common mechanisms including neuro-inflammation, oxidative stress and neuro-apoptosis. Hydrogen sulfide (H2S), known as a toxic gas with the smell of rotten eggs, is increasingly proposed as potential therapeutic target that influences these mechanisms in different ways. Abnormal H2S generation and metabolism were also found in most neurodegenerative disorders. Interestingly, in the central nervous system (CNS) H2S exerts anti-inflammatory, antioxidant and anti-apoptotic effects which are related to neurodegenerative diseases. The aim of this paper is to present the current understanding of H2S-induced functions in the brain, and its potential therapeutic value in neurodegenerative diseases. The emphasis will be on AD, PD, amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). It is concluded that due to its neuroprotective functions, H2S is a promising target for future research and treatment of neurodegenerative diseases.

Item Type:	Thesis (Bachelor's Thesis)
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	15 Feb 2018 07:57
Last Modified:	15 Feb 2018 07:57
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/11814

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