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Liposomes or archaeosomes: a new vaccine delivery system?

Postma, E.D. (2014) Liposomes or archaeosomes: a new vaccine delivery system? Bachelor's Thesis, Biology.

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Vaccination is one of the most important medical interventions with a major impact on global health. In the past attenuated or inactivated pathogens were used in order to prevent bacterial or viral infections. Nowadays subunit vaccines are used because of their safety profile. However, due to their poor immunogenicity, these kinds of vaccines need adjuvants and particulate vaccines are a very promising option. Liposomes and archaeosomes belong to this class and they are optimal candidates for particulate vaccines due to their high safety profile and versatility. In this study the physiochemical properties of liposomes and archaeosomes are analysed and compared on the basis of their effect on the immunogenicity, moreover the possible advances in the modification of the physiochemical characteristics of the vesicles and how these changes affect the immune response are discussed. The archaeal lipids are well known to be more stable than conventional ester lipids due to their unsaturated isoprenoid chains ether linked to a sn-glycerol-1-phosphate backbone and are inherently immunogenic. Despite these features, the liposomes have overcome these problems by incorporating co-adjuvants and by the use of synthetic lipids. For each pathogen/disease a particular immune response is required to efficiently battle it, therefore the adjuvant formulation is designed depending on the kind of immune response that you want to trigger. In fact the different nature and the different physiochemical properties elicit different immune responses. The physiochemical properties that are considered in this review concern the choice of headgroup, which affects the recognition, binding and uptake of the vesicles, the membrane fluidity and the shape of the vesicles.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:57
Last Modified: 15 Feb 2018 07:57

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