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Essay: Foreign body giant cells in the foreign body reaction to implanted biomaterials, a systematic review

Schepers, T. (2015) Essay: Foreign body giant cells in the foreign body reaction to implanted biomaterials, a systematic review. Bachelor's Thesis, Biology.

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Foreign body giant cells (FBGC) are important cells in the foreign body response (FBR), as they are known to be able to degenerate biomaterials, by oxidation, hydrolysis and MMP secretion. It remains difficult to discriminate between FBGC and other giant cells such as osteoclasts, therefore several established markers will be discussed. Also several targets for the inhibition of FBGC will be discussed as this migth prove to become clinically relevant in order to suppress biomaterial degeneration by FBGC. The reaction of FBGC to several different biomaterials will be discussed as well as there are no reviews discussing this elaborately. Also the comparison of FBGC to mononuclear macrophages was made. The review concludes that FBGC formation varies between different species of animals, different biomaterials, different compositions of the same biomaterial, different surfaces of the biomaterial, as well as different sites of implantation of the biomaterial. Contreversial results have been found with regard to differences between FBGC and mononuclear macrophages with regard to phagocytosis and the secretion of degerative enzymes. However in gerenal mononuclear macrophages seem to display phagocytosis whereas FBGC are found to surround the biomaterial. FBGC were found to be able to secrete degenerative enzymes, cytokines, chemokines, ECM, and angiogenic mediators.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:03
Last Modified: 15 Feb 2018 08:03

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