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Essay: The complement system in kidney diseases: current therapeutic options and upcoming drugs

Ettema, M.A.B. (2015) Essay: The complement system in kidney diseases: current therapeutic options and upcoming drugs. Bachelor's Thesis, Biology.

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A part of the innate immune system is the complement system. The complement system consists of three pathways which can be activated in different ways. It turned out that the complement system is of great importance in kidney diseases, and especially the alternative pathway plays a major role. Currently there are two approved drugs on the market which can intervene with the complement system and show beneficial effects in certain diseases. These are the drugs eculizumab and C1 inhibitors. However, eculizumab is very expensive and like C1 inhibitors, not that effective in some diseases. Therefore, it is important to look at inhibition of the complement system in different levels, also to minimalize the side effects. Some studies have been done for other drugs on other levels then eculizumab and C1 inhibitors. One of these drugs is compastin, which interferes with the complement system at C3, which could possible cause many side effects. Another target which is studied now is properdin, which is a specific factor for the alternative pathway. This seems to be a promising target, because other pathways will stay intact and inhibition in vivo already showed some promising effects. Then, there are receptor antagonists. Discussed in this review is the C5a receptor antagonist CCX168, which will be tested in a clinical trial this year. And as last, polysaccharide glycosaminoglycans are mentioned as a future target, because they interfere a lot with the complement system and have shown some inhibiting effects. Overall, there are some promising studies for new drugs to intervene with the complement system. Besides that, new studies should mainly focus on specific inhibiting the complement system to prevent side effects as many as possible.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:04
Last Modified: 15 Feb 2018 08:04

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