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Essay: Brown adipose tissue: a potential link to Raynaud’s phenomenon

Dekker, T. (2015) Essay: Brown adipose tissue: a potential link to Raynaud’s phenomenon. Bachelor's Thesis, Biology.

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Raynaud’s phenomenon is a condition that is characterized by exaggerated vasoconstriction of the peripheral vasculature. This response is most often seen when subjected to cold exposure or stress. Unfortunately the mechanism leading to Raynaud’s phenomenon is largely unknown. However, people suffering from Raynaud’s phenomenon have a lower core body temperature than controls. The lower core body temperature can be related to brown adipose tissue (BAT), because BAT generates heat. Brown adipose tissue thermogenesis can be disrupted by an impairment in the proteins that are responsible for thermogenesis, for example uncoupling protein 1 (UCP1). Lacking UCP1 impairs thermogenesis. Not only BAT itself could be impaired, also the sympathetic nervous system could be impaired. The sympathetic nervous system is responsible for stimulating BAT to generate heat. If this stimulation has been reduced, BAT thermogenesis will decrease. Local adipose tissue that shares many similarities with BAT is peripheral vascular adipose tissue (PVAT). PVAT can reduce vasoconstriction by releasing vasodilatating agents, but also by thermogenesis. In conclusion, Raynaud’s phenomenon may be caused by an impairment in BAT thermogenesis.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:04
Last Modified: 15 Feb 2018 08:04

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