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Adolescent social housing conditions and resilience to adult social stress

Westgeest, Y. (2014) Adolescent social housing conditions and resilience to adult social stress. Master's Thesis / Essay, Biology.

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This research focused on finding indications of increased resilience to social stress by social housing conditions during adolescence. During this period, low aggressive Wistar rats were housed in pairs, in a colony with other Wistar rats or in a mixed colony with socially more skillful Wild-Type Groningen (WTG) rat for 25 days (PND 40 -75). After these different housing conditions, rats were housed individually and subjected to a social stressful event: a defeat in the resident-intruder paradigm. Severity of anxiety and stress was measured by an open field test, the elevated plus maze, serotonin 1A receptor sensitivity, changes in circadian body temperature, locomotor activity in the home cage and indicators of anhedonia such as sucrose consumption and behavioural and physiological anticipation to a reward. Test results, however, show no direct indications of changes in resilient behaviour. For future research it is recommended that in mixed strain social colonies WTG rats are used that exceed Wistar rats in age. This age difference will stimulate defensive behaviour of the Wistar rats that might result in an increased resilience towards social stress in later life.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:04
Last Modified: 15 Feb 2018 08:04

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