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Dengue vaccines that induce a T-cell response: a new opportunity

Voshart, D.C. (2015) Dengue vaccines that induce a T-cell response: a new opportunity. Bachelor's Thesis, Biology.

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Dengue virus (DENV) is endemic in a large part of South Asia, the America’s and Africa. The virus has four serotypes and each of them can cause plasma leakage, shock and even death. Vaccine research focuses primarily on vaccines that induce an antibody response, but the most important vaccine candidate doing this, recently failed to induce immunity against all serotypes. This thesis investigates whether dengue vaccine research should focus more on eliciting T-cell mediated immunity. T-cells might contribute to disease pathogenesis, but overall, the T-cell response against DENV is beneficial for the individual. Furthermore, although original antigenic sin of T-cells occurs during a secondary T-cell infection, this has proven to be non-pathogenic. It also does not reduce the efficiency of the T-cell response to DENV infection. Lastly, with a vaccine that only induces a T-cell response, the antibody-dependent enhancement of infection can be avoided. In conclusion, dengue vaccine research should focus more on T-cell response for both a vaccine that only evokes a T-cell response and a vaccine that elicits a T-cell and an antibody response.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:05
Last Modified: 15 Feb 2018 08:05

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