Algra, A. (2016) Role of IL-23 in rheumatoid arthritis. Bachelor's Thesis, Biology.
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Abstract
Rheumatoid Arthritis (RA) is a multifactorial, auto-immune disease. It is characterized by systemic inflammation, synovitis and movement-impaired joints. Genetic susceptibility and environmental, as well as a dysfunctional immune system play key roles in the progression of disease. IL-23, a cytokine belonging to the IL-12 cytokine family is essential for the differentiation an survivability of Th17 cells, a T lymphocyte involved in the production and secretion of the pro-inflammatory cytokine IL-17. IL-23 is known to be highly expressed in destructive synovial tissue in RA. The IL-23/IL-17 pathway could possibly underlie the pathogenesis of RA, which is unfortunately still not fully understood. The cytokine IL-23 is considered to be a promising therapeutical target in RA, which deserves more research.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 15 Feb 2018 08:11 |
| Last Modified: | 15 Feb 2018 08:11 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/13715 |
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