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Role of IL-23 in rheumatoid arthritis

Algra, A. (2016) Role of IL-23 in rheumatoid arthritis. Bachelor's Thesis, Biology.

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Rheumatoid Arthritis (RA) is a multifactorial, auto-immune disease. It is characterized by systemic inflammation, synovitis and movement-impaired joints. Genetic susceptibility and environmental, as well as a dysfunctional immune system play key roles in the progression of disease. IL-23, a cytokine belonging to the IL-12 cytokine family is essential for the differentiation an survivability of Th17 cells, a T lymphocyte involved in the production and secretion of the pro-inflammatory cytokine IL-17. IL-23 is known to be highly expressed in destructive synovial tissue in RA. The IL-23/IL-17 pathway could possibly underlie the pathogenesis of RA, which is unfortunately still not fully understood. The cytokine IL-23 is considered to be a promising therapeutical target in RA, which deserves more research.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:11
Last Modified: 15 Feb 2018 08:11

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