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Controlling Transcription and Cell fate during cellular reprogramming and differentiation

Dekker, B. (2016) Controlling Transcription and Cell fate during cellular reprogramming and differentiation. Master's Thesis / Essay, Biomedical Sciences.

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Induced pluripotent stem cells provide a promising platform for regenerative medicine. Expression of four transcription factors, Oct4, Sox2, Klf4 and c-Myc (OSKM), can already induce pluripotency from somatic cells. Nevertheless, introducing OSKM factors are bringing concerns regarding inducing tumorigenesis. However, inactivate genome editing tools (ZF, TALE and Crispr-Cas9) have evolved quickly to control gene expression either directly or indirectly without altering the DNA sequence. In this review, we highlight the different uses of those tools for inducing pluripotency and differentiation. In addition, the different aspects of inducing pluripotency and the barriers preventing induced pluripotency

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:11
Last Modified: 15 Feb 2018 08:11

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