Measuring insulin resistance in clinical practice

Kraeima, B. (2016) Measuring insulin resistance in clinical practice. Bachelor's Thesis, Biology.

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Abstract

Insulin resistance is a fundamental factor in developing type 2 diabetes, which is a chronic metabolic disease with globally increasing number of diagnoses. Insulin resistance can still be reversed, therefore a sensor system capable of measuring insulin resistance in a clinical practice becomes increasingly desirable. This research defines the requirements of such a sensor system and evaluates the conventional methods available for measuring insulin resistance, furthermore possible innovative solutions are discussed. A clinical based sensor system requires a non-invasive measurement which can distinguish clearly between healthy, insulin resistant and diabetic test subjects. Furthermore no dietary preparations or extensive laboratory analysis should be required. All conventional methods for evaluating insulin sensitivity have limited value for clinical practice mainly due to their invasiveness, whereas new unconventional methods either lack significance in results or require more research. However both the 13C-glucose breath test and the urinary RBP4 measurement method have potential if further research can improve the significance of the results.

Item Type:	Thesis (Bachelor's Thesis)
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	15 Feb 2018 08:11
Last Modified:	15 Feb 2018 08:11
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/13771

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