Cellular Senescence: Spotlight on the Mitochondria

Mavrova, S. (2016) Cellular Senescence: Spotlight on the Mitochondria. Research Project 2 (major thesis), Biomedical Sciences.

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Abstract

In order to respond to internal and environmental stress, cells developed different stress response mechanisms. Such a mechanism is cellular senescence, which leads to permanent cell-cycle arrest of proliferative cells. Not so long ago, it has become evident that senescent cells have serious alterations in their gene expression and function. Furthermore, paradoxical to their anti-tumorigenic function, these cells can promote tumor formation and progression along with other disorders. This feature of the senescent cells is due to their altered secretome, called senescence associated secretory phenotype (SASP). Recent studies identified that SASP is regulated by the activity of the mammalian target of rapamycin complex 1 (mTORC1) and can be abrogated by the administration of rapamycin or complete clearance of the mitochondria. In this essay, the molecular mechanisms behind the SASP regulation will be discussed together with the mitochondrial involvement in this process.

Item Type:	Thesis (Research Project 2 (major thesis))
Degree programme:	Biomedical Sciences
Thesis type:	Research Project 2 (major thesis)
Language:	English
Date Deposited:	15 Feb 2018 08:13
Last Modified:	15 Feb 2018 08:13
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/14013

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