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Fluorescent Nanodiamonds for cell tracking and nanoscale temperature sensing in breast carcinoma

Hinterding, S.R. (2016) Fluorescent Nanodiamonds for cell tracking and nanoscale temperature sensing in breast carcinoma. Bachelor's Thesis, Biology.

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Fluorescent nanodiamonds (FNDs) have recently developed into a key element in the interdisciplinary fields between biology, chemistry, physics and materials sciences. The FND is a promising nanoprobe, owing its properties to a fluorescent defect, the so-called nitrogen-vacancy (NV-) center. This NV- center has a number of impressive optical and magnetic properties, for instance emitting bright fluorescence at 685 nm. The produced fluorescence has excellent photo stability. The past decade, studies confirmed that FNDs are also biocompatible and nontoxic. Altogether, these features make FNDs a potential candidate for long term imaging in vivo and got them up for debate in different fields of medicine. One of those fields is radiotherapy, which is an important component of anti-cancer treatment. Some patients do not respond to radiotherapy and up to now clinicians are unable to predict which patients have high risk at reappearance after therapy. In this review, breast cancer will be used as a model for introducing FNDs as a marker for bio-imaging. Breast cancer is the most common cancer affecting women from all over the world, therefore early detection and more knowledge about this type of cancer will provide a brighter future for these women. This paper provides a summary of the used ‘triple assessment’, which includes clinical examination, imaging and needle biopsy, the cancer therapy and more knowledge about the tumor’s microenvironment. Additionally, the problem of targeting the DNA damage is mentioned and in which manner more knowledge about this can be obtained. This will involve long-term cell tracking and nanoscale temperature sensing using FNDs.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:13
Last Modified: 15 Feb 2018 08:13

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