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Learning from immune evading properties of tumours for transplantation immunology

Willemsen, R. (2016) Learning from immune evading properties of tumours for transplantation immunology. Bachelor's Thesis, Biology.

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Transplantations carry the risk of complications. Acute rejections by the host mediated by T lymphocytes and macrophages which occur days or weeks after transplantation, force the recipient to take immune suppressive agents. These immune suppressive agents, which often need to be taken lifelong, have many adverse side effects. Furthermore, these drugs are not capable of suppressing chronic rejection, which can develop insidiously in the host and causes fibrosis in the graft. If the allograft could be made less visible or recognisable for the immune system of the host, the need for immune suppressive drugs would be reduced. An already existing example of immune system evading tissue is cancer. Cancer can circumvent the immune system in several ways, a number of which are described in this thesis. In this study, lessons are drawn from immune evasion strategies of cancer, with a view to identifying possible solutions for transplant rejection and alternatives for immune suppressive therapy. The results of the study indicate that right now there are no known techniques for the incorporation of immune evasive genes or transcription factors in solid organs of donor transplants, but that genetic changes can be induced in bioengineered organs which are made from scratch.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:14
Last Modified: 15 Feb 2018 08:14

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