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Cholesterol degradation: a promising novel drug target against Tuberculosis

Blom, P. (2016) Cholesterol degradation: a promising novel drug target against Tuberculosis. Bachelor's Thesis, Biology.

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One third of the world population is infected by Mycobacterium tuberculosis. Although for most patients, the disease is in its latent phase, this still poses a major threat for global health. Especially as drug resistant strains of this bacterium arise, effectively treating tuberculosis becomes increasingly difficult. New drugs against tuberculosis are constantly being developed, but the pipeline may be too narrow and multiple strategies have to be invoked to keep ahead of this disease. Alongside improvement of existing drugs and high throughput screening, target based drug design is one of the viable strategies. An interesting target is the cholesterol catabolism of Mtb as intervention in this pathway results in both accumulation of toxic intermediates and deprivation from an important energy and carbon source. Therefore successful inhibition of one or several of the key enzymes for this pathway, may be a decent way to combat Mtb. All known enzymes are discussed in this thesis on their potential to become a viable drug target, and for what enzymes further characterisation is necessary. Although not the entire pathway has yet been fully understood, several candidate enzymes for drug development arise, and their inhibitors may be leads for future clinical trials.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:24
Last Modified: 15 Feb 2018 08:24

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