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The effects of leukemia on niche - Hematopoietic stem cell interactions

Dijkstra, T. (2016) The effects of leukemia on niche - Hematopoietic stem cell interactions. Bachelor's Thesis, Biology.

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Hematopoietic stem cells (HSCs) are localised in a bone marrow niche, nearby the trabecular bone or perivascular areas like blood vessels. Important characteristics of HSCs like quiescence, self-renewal and differentiation are maintained by the diverse cells associated with the niche. The most important niche cells are osteolineage cells, mesenchymal stem cells and endothelial cells, which can regulate HSCs via secreted factors or via direct interactions with plasma membrane proteins expressed on HSCs. Furthermore also the nervous system in the niche has recently been shown to be important for maintenance of HSCs. Leukemia is a disease in which hematopoiesis, the formation of blood, is severely impaired. Leukemia can be caused by a number of genetic mutations that accumulate in the progenitor cell or HSC to form a leukemic stem cell. Besides intracellular changes in LSCs that impair normal hematopoiesis, the LSC is also able to impact on and even change the niche. This can for instance occur by secreting factors such as inflammatory cytokines, or via upregulation of CXCL12, a molecule that affects the localisation of HSCs. Ultimately, these changes in the niche might favor leukemogenesis over normal hematopoiesis.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:24
Last Modified: 15 Feb 2018 08:24

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