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The role of macrophage phenotypes M1 and M2 in the foreign body reaction

Malutama Lopes, J.E. (2016) The role of macrophage phenotypes M1 and M2 in the foreign body reaction. Bachelor's Thesis, Biology.

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Clinically successful integration of a biomaterial in a host tissue is a big challenge the tissue engineering field faces. The foreign body reaction consist of a series of inflammatory processes, which leads to fibrosis and encapsulation of the biomaterial. Macrophages play a key role in this reaction. They can adopt different phenotypes; a inflammatory macrophage phenotype (M1) and a regulatory or anti-inflammatory phenotype (M2). The severity of the foreign body reaction immediately after transplantation determines the success of transplantation and is greatly dependent of the biomaterials surface. Several immunomodulatory design strategies have been developed, trying to facilitate a switch in the host tissue macrophages from M1 to M2. In this thesis, the role of M1 and M2 macrophages will be discussed, as well how to activate macrophages to a desired phenotype. In addition, immunomodulatory strategies for better implant integration will be investigated.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:25
Last Modified: 15 Feb 2018 08:25

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