CIN a cause, a consequence or something in between in tumour development

Kok Y.P. (2016) CIN a cause, a consequence or something in between in tumour development. Master's Thesis / Essay, Biology.

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Abstract

Chromosome instability (CIN) is the process that leads to missegregation of chromosomes during cell division. CIN increases the likelihood that upon each cell division daughter cells end up with an aberrant number of chromosomes a status defined as aneuploidy. Two out of three solid tumours exhibit aneuploidy. While CIN is observed in the majority of tumours, mutations in genes that are involved in faithful chromosome segregation are rare. Furthermore, in vitro studies show that CIN decreases cellular fitness and is often detrimental. In vivo studies indicate a role for CIN in the development of tumours. However, if CIN is an initiator or facilitator in tumour development remains to be defined. CIN renders an increased rate of acquiring mutations due to chromosomal missegregation. Thus, the proposed role of CIN might be as the mechanism that promotes the transformation of non-malignant cells to malignant cells

Item Type:	Thesis (Master's Thesis / Essay)
Degree programme:	Biology
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	15 Feb 2018 08:25
Last Modified:	15 Feb 2018 08:25
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/14652

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