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On the origin of cancer - Analysis of two models on cancer evolution

Dillingh, L.S. (2016) On the origin of cancer - Analysis of two models on cancer evolution. Bachelor's Thesis, Biology.

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Although much research is done focussing on early diagnosis and treatment of cancer, less is known about the origin and evolution of cancer. At the beginning of the 20th century different models were postulated to understand tumorigenesis, like the somatic mutation theory. Aneuploidy as a driver for tumorigenesis was also already mentioned by Theodor Boveri. In current research on the origin and evolution of tumours, the researchers are divided in two teams. The mutator mutation phenotype model suggest tumorigenesis starts when specific mutations occur in mutator genes, normally involved in DNA repair and genomic stability. The tumorigenesis by aneuploidy model explains tumorigenesis by the fact that more than 75% of all solid tumours are aneuploid, thus have an abnormal number of chromosomes and this abnormality is the reason why tumours develop to a detectable tumour. In this thesis both models will be compared based on experimental evidence given by different researchers. The clinical relevance of the models will be briefly explained. This information will be used to answer the question if tumorigenesis and tumour evolution is best explained by the model of tumorigenesis by aneuploidy or the model of mutator mutation phenotype. After comparison of the given evidence, an attempt will be made to combine both models to a model that is corresponding with all the evidence.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:25
Last Modified: 15 Feb 2018 08:25

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