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Biocompatibility of neural electrodes

Boer, J.W. de (2016) Biocompatibility of neural electrodes. Master's Thesis / Essay, Biomedical Sciences.

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A healthy functioning brain is crucial for proper sensory- and motor processing. Neurological disorders change normal neuronal activity, which can impair cognition, sensory and motor functions. Electrodes implanted in the brain improve these functions by interacting with electrically excitable tissue. The central nervous system (CNS) has limited regenerative potential, but seems tolerant with regard to biomaterial implants. However, the foreign body response (FBR) leads to structural and cellular changes around the implant, that affect both nervous tissue and electrode functionality. Implantation of electrodes in the CNS activates the immune system through surgical damage and foreign material introduction. The cellular and molecular components can stimulate protective and toxic pathways, limiting the application of this therapy. Approaches for future development include inflammation prevention, mimicking of brain tissue characteristics and promoting recovery. This essay reviews strategies for new neural electrode applications and the interaction of electrodes with neurons and the resident immune cells of the nervous tissue.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:26
Last Modified: 15 Feb 2018 08:26

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