How Wnt/β-Catenin, TGF-β/BMP signalling effect senescence via polycomb.

Ensink, F. (2016) How Wnt/β-Catenin, TGF-β/BMP signalling effect senescence via polycomb. Research Project 2 (major thesis), Biomedical Sciences.

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Abstract

Aging and age related diseases are accountable for most of the deaths world-wide. Many of these age related diseases are associated with an increase in senescent cells. A combination of increased induction of senescence and lowered clearance of senescent cells by the aged immune system is accountable for this increase in senescence. The secretory phenotype of senescent cells affects the stem cell niche and lowers the stem cells ability to proliferate and differentiate, resulting in Impaired tissue regeneration. Polycomb related complexes have been shown to regulate senescence. Polycomb repressive complex 1 expression is associated with a reduction of senescent cell markers. In this paper polycomb related complexes and senescence are linked via Wnt/β-Catenin, TGF-β and BMP signalling. The increased amounts of senescent cells in aged tissue effects TGF-β, BMP and Wnt signalling. These alterations in TGF-β, BMP and Wnt signalling lead to different polycomb repressive complex (PRC) compositions. Different PRC compositions again affect TGF-β, BMP and Wnt signalling. In this review it is shown that the increased amounts of senescent cells alter the balance in TGF-β, BMP and Wnt signalling in a way, which stimulates PRCs to facilitate senescence and thereby create an unwanted positive feedback loop.

Item Type:	Thesis (Research Project 2 (major thesis))
Degree programme:	Biomedical Sciences
Thesis type:	Research Project 2 (major thesis)
Language:	English
Date Deposited:	15 Feb 2018 08:26
Last Modified:	15 Feb 2018 08:26
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/14719

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