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Reactive Oxygen Species contribute to antibiotic efficacy

Koning, M. de (2016) Reactive Oxygen Species contribute to antibiotic efficacy. Master's Thesis / Essay, Molecular Biology and Biotechnology (2016-2019).

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As multi drug resistant bacterial strains are becoming a significant problem within our current society, there is a continuous need for developments in the field of antibiotics. Unfortunately, over the last two decades, the advancements in this field did not lead towards a usable solution for the current problems. Around one decade ago, a possible link between Reactive Oxygen Species and the lethality of antibiotics has been suggested. By acquiring knowledge on this possible linkage, a controversy on the contribution of Reactive Oxygen Species towards antibiotic efficacy was initiated. This resulted in experiments suggesting that Reactive Oxygen Species do contribute to this process, mainly when bactericidal antibiotics are combined with the presence of molecular oxygen. This contribution could give new options in utilizing current antibiotics and elucidating unknown relations between stress impulses like antibiotics and the protective systems developing within bacteria.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Molecular Biology and Biotechnology (2016-2019)
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:26
Last Modified: 15 Feb 2018 08:26

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