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Alzheimer's Disease: The Amyloid Hypothesis on Trial

Oost, W. (2017) Alzheimer's Disease: The Amyloid Hypothesis on Trial. Bachelor's Thesis, Biology.

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Alzheimer’s Disease (AD) is an common, irreversible neurodegenerative condition and is considered as one of the biggest global public health challenges. The amyloid hypothesis of Alzheimer’s disease has been the foundation of efforts to understand the disease for almost 25 years. The hypothesis proposes that deposition of beta-amyloid (Aβ) protein is central to the pathogenesis of the disorder. However, recently its validity has been called into question after the failure of Aβ-targeting therapies in clinical trials, suggesting that the amyloid pathology lies downstream of (an)other cellular event(s) that is/are responsible for AD pathogenesis. Nonetheless, there could have been insufficient target engagement or the drugs may have been administered too late in the disease process. Studies to investigate this matter are on their way, until then we can not draw harsh conclusions on giving up on the amyloid hypothesis. However, AD is probably much more complicated and there are probably many roads leading to the disease. Therefore, we need focus on other therapeutic strategies as well.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:26
Last Modified: 15 Feb 2018 08:26

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