Impact of antibiotics in early life on development of the intestinal microbiota

Jong, H. de (2017) Impact of antibiotics in early life on development of the intestinal microbiota. Bachelor's Thesis, Biology.

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Abstract

The dynamic gut microbial microbiota is susceptible to disturbances before stabilizing into a mature microbiome community after the first 3 years of life. One of the factors that is associated with marked changes in the gut microbiota composition, is the use of antibiotics. This can have immediate effects such as infections of opportunistic pathogens and adds disadvantages of the increased resistant organisms in the gut microbiota. Microbiome alterations by antibiotics can also have indirect effect on health in the long-term and has been associated with an increased risk of a wide range of diseases and syndromes, such as obesity, diabetic, inflammatory bowel disease, asthma and allergies. It has been shown that antibiotic exposure decreases the gut microbiota diversity and affects gene expression, protein activity and overall metabolisms. The mutualistic microbes in the intestinal gut tract have important functions such as nutrient absorption and modulation, and the development of the mucosal immune system. Therefore, antibiotic exposure can alter basic physiological processes. It is important to understand the impact of antibiotics on the development of the gut microbiome and for the increasing concern that antibiotics may have long-term consequences. Strategies are needed to minimize the negative consequences of antibiotics. Probiotics, prebiotics and fecal microbiota transplantations are aimed to restore the imbalanced gut microbiota and seem promising strategies.

Item Type:	Thesis (Bachelor's Thesis)
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	15 Feb 2018 08:27
Last Modified:	15 Feb 2018 08:27
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/15149

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