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The efficiency of an affordable reusable oxygenator for warm kidney machine perfusion

Ottens, S.A. (2017) The efficiency of an affordable reusable oxygenator for warm kidney machine perfusion. Master's Internship Report, Biomedical Engineering.

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Objective: Transplant medicine is a hot topic in current research, especially the preservation part. A lot of research is being done to improve the machine perfusion method, however this is expensive. To reduce costs, the University Medical Center Groningen (UMCG) is working on a budget perfusion system. One of the expensive parts in the current circuits is the oxygenator that provides oxygen to the organ and extracts CO2. An affordable version was designed and tested before with water. Goal of this study is to investigate if the budget oxygenator is efficient enough with blood as perfusion medium, to provide a kidney with sufficient oxygen. Methods: During this experiments three oxygenators were tested: MEDOS Hilite 1000, Hemocor HF mini and the UMCG-designed oxygenator. These oxygenators are singly connected to a mock circulation loop flushed with heparinized porcine blood. Flows from 50-500 mL/min with FiO2’s of 21, 50 and 100% were tested at gas:blood flow ratios of 1:1, 0.5:1 and 2:1. Every minute the pressure, flow, temperature and pO2 of the arterial and venous blood were measured. At the highest flows, blood gases were taken and analyzed as well. Due to an adaption after previous research, the UMCG oxygenator has been tested with water flushing through the circuit first to see if it could oxygenate at higher flows as well. Results: The UMCG-designed oxygenator is able to provide gas exchange in water at higher flows. In blood the oxygen delivery is higher than the oxygen demand of a kidney at flows 100-300 mL/min with FiO2 100%: 45.0-557.4 mL/min. The inspiration fraction of 21% gives higher oxygen delivery at flows from 300-500 mL/min (excluding ratio 0.5:1 at flow 500 mL/min): 50.4-194.0 mL/min. Comparing the UMCG oxygenator to the MEDOS Hilite 1000, the oxygen delivery is less and more unstable. Conclusion & discussion: It seems that the UMCG-designed oxygenator is not stable enough to provide a porcine kidney with oxygen during perfusion. This might be due to the design, whereas the blood does not flow optimally through the oxygenator. As this is based on single results, further research should be done to draw reliable conclusions and improve the oxygenation capacity of the oxygenator.

Item Type: Thesis (Master's Internship Report)
Degree programme: Biomedical Engineering
Thesis type: Master's Internship Report
Language: English
Date Deposited: 15 Feb 2018 08:28
Last Modified: 15 Feb 2018 08:28

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