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ADHD and the circadian rhythm

Borneman, A (2016) ADHD and the circadian rhythm. Master's Thesis / Essay, Biomedical Sciences.

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Individuals with ADHD always experience difficulty concentrating on a specific task, which interferes with the ability to learn, work and engage in social activities. This is thought to be caused by hypofunction of the dopaminergic system. However, the exact mechanisms is still unknown and a lot of theories exist about the underlying cause. Individuals with ADHD often suffer from sleep problems, which could be caused by their hyperactivity. Some studies however, suggest that it is caused by the stimulant medication. Individuals with ADHD medication had an increase in sleep problems compared to individuals without medication. The exact cause of this is unknown, however some studies suggest that the medication disturbs the circadian rhythm. Multiple studies found that MPH and ATO influenced the expression of certain clock genes, like Per1, Per2 and CLOCK. Further, they found a shift in the SCN rhythm. A different studies suggest however, that ADHD is caused by a mutation in circadian clock genes, instead that the dysregulation is a consequence of the medication. More research is necessary to investigate the underlying mechanism of the development of ADHD and to determine the effects of the medication on the circadian rhythm.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:28
Last Modified: 15 Feb 2018 08:28

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