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Targeting mechanisms of tail anchored proteins in Yeast and mammalian cells

Ettema, T.W. (2017) Targeting mechanisms of tail anchored proteins in Yeast and mammalian cells. Bachelor's Thesis, Biology.

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Abstract - Tail anchored (TA) proteins constitute a diverse group of proteins that share a distinct way of anchoring to biological membranes. Due to their topology TA proteins are obliged to use a post-translational mode of insertion. Since the discovery of TA proteins several research groups have tried to characterize the different targeting mechanisms that these proteins use. Until now several factors have been identified ranging from physicochemical properties of the transmembrane domain (TMD), to cytosolic chaperones that guide TA proteins to their correct membranes. Since TA proteins are located to several different locations within the cell, there is not a single pathway that is used by all TA proteins. Different locations use different mechanisms. This paper will give an overview of the targeting mechanisms, that have been identified so far, to the endoplasmic reticulum (ER), the mitochondrial outer membrane (MOM) and peroxisomes.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:28
Last Modified: 15 Feb 2018 08:28

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