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Thesis: The direct effect of macrophages on wound healing and fibrosis

Kommers, R. (2017) Thesis: The direct effect of macrophages on wound healing and fibrosis. Bachelor's Thesis, Life Science and Technology.

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Wound healing is a multiple stage wound healing process in which damaged tissue is being repaired, but an impaired pathological repair can result in fibrosis. In fibrosis a damaged tissue is incompletely repaired following an elevated or persistent inflammation resulting in a hardened and impaired functioning tissue or a scar, primarily consisting of collagen type I. One of the main regulators in this multistage process are macrophages which act as first responders, in the early stages, by clearing and phagocytising wound debris. In the following stages they act as regulators by secreting several cytokines of which TGF-β is the most important by which they activate myofibroblasts to produce collagen. Besides these indirect regulatory effect of macrophages a more direct effect of macrophages on the collagen deposition is proposed. Macrophages producing collagen themselves are one of the possibilities but although research demonstrated that macrophages are capable of producing collagen and other ECM products no evidence for collagen I producing macrophages has been found. There is also a possibility for a fibrolytic phenotype macrophage altering and determining final ECM composition by for example MMP’s and TIMPS. But also no evidence for such a phenotypic macrophage has been found, although macrophages are capable and do secrete MMP’s but mainly in the early stages of wound healing favouring cell migration. Another possibility of contribution to the collagen deposition would be the transdifferentiation of macrophages into collagen producing myofibroblasts. Although there is evidence for a large portion of myofibroblasts originating from macrophages ,ranging from %50 to %80 of the total myofibroblast population, the functionality of these myofibroblasts has not been researched and therefore it remains unknown what the actual contribution of these macrophage derived myofibroblasts is to the total collagen deposition.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Life Science and Technology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:30
Last Modified: 15 Feb 2018 08:30

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