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Centrosome segregation and its relevance in asymmetric cell division

Pliego Caballero, M (2017) Centrosome segregation and its relevance in asymmetric cell division. Master's Thesis / Essay, Biomedical Sciences.

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Stem cells can divide asymmetrically, giving rise to a self-renewing daughter stem cell and another cell that undergoes differentiation. Cell intrinsic and extrinsic factors are involved in the fate determination of the progeny. Since the last decade, centrosomes have also been suggested to contribute to the cell fate through their stereotypical segregation. While some types of stem cells seem to retain the older of the parental centrosomes and the differentiating sister inherits the younger centrosome, for other types of stem cells the inheritance is inversed. In this assay, the asymmetric inheritance of centrosomes is reviewed, with the aim to clarify whether this influences the cell fate in asymmetric stem cell divisions.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 08:32
Last Modified: 15 Feb 2018 08:32

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