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The influence of sleep deprivation on the development of Alzheimer's disease

Veeningen, N. (2017) The influence of sleep deprivation on the development of Alzheimer's disease. Bachelor's Thesis, Biology.

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Alzheimer’s disease (AD) is a neurodegenerative disorder and is the principal cause of dementia in elderly people. The disease is characterized by neuronal senile plaques and neurofibrillary tangles in the patient's brain. These plaques consist out of aggregated Aβ. In 2012 a new clearance system, the glymphatic system, used to remove toxic metabolites has been discovered. The glymphatic system is able to eliminate Aβ from the brain, hereby preventing it from aggregating. Because the system is highly active during sleep, it is considered that sleep deprivation contributes to an increase in Aβ. Research is now focusing on the possibility of a relationship between sleep deprivation and the development of AD. This thesis will highlight several possibilities on how sleep, especially sleep deprivation, could influence the development of AD.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:32
Last Modified: 15 Feb 2018 08:32

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