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Role of MMP-13 in Remodeling of Hepatic Fibrosis

Kuipers, T.N. (2017) Role of MMP-13 in Remodeling of Hepatic Fibrosis. Bachelor's Thesis, Life Science and Technology.

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Matrix metalloproteases (MMP) are responsible for degradation of ECM components in fibrotic tissues. It is thought that especially MMP-13, a homolog of human MMP-1, may be the key for reversal of liver cirrhosis. This is because it is able to degrade the collagens found in fibrotic ECM. However, this MMP is only found in the early phase of hepatic fibrosis. Both overexpression of MMP-13 and apoptosis of hepatic stellate cells (HSC), which are the major collagen producing cells, have shown promising results in remodeling to a near-normal liver architecture. Therapeutic treatment of the fibrotic tissue with both these methods, might result in a clearance of the hepatic cirrhosis. However, a lot is not yet known about this enzyme, and a lot of research needs to be done.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Life Science and Technology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 08:32
Last Modified: 15 Feb 2018 08:32

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