The ageing extracellular matrix of the lung

Boekema, P.H. (2017) The ageing extracellular matrix of the lung. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

Ageing is characterized by a progressive decline of physiological integrity leading to impaired function and increased vulnerability for the development of diseases. Nowadays, ageing research emphasizes nine hallmarks that have been defined as common denominators in ageing, while less attention is paid to structural alterations of the extracellular matrix (ECM). In the ageing lung, substantial alterations of the ECM have been observed, as well as in respiratory diseases like chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). In this essay, we discuss whether the loss of proteostasis affects the integrity of the lung ECM in ageing and respiratory diseases. We have found that expression of mutant alpha-1 antitrypsin (A1AT) induced stress responses in endoplasmic reticulum via NF - kB and eLF2 in epithelial lungs cells. Further, we found that fibronectin EDA is necessary for TGF-b induced fibroblast differentiation. Further, we have discussed that fibronectin EDA induced ER stress responses, which is ameliorated by the introduction of chaperones. Therefore, it is reasonable to suggest that both A1AT and fibronectin EDA act separately in ER stress. We concluded that impaired proteostasis is accompanied by dysregulation of the ECM.

Item Type:	Thesis (Master's Thesis / Essay)
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	15 Feb 2018 08:35
Last Modified:	15 Feb 2018 08:35
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/16422

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