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HSP90 as a target for cancer treatment

Hoskens, Dana (2018) HSP90 as a target for cancer treatment. Bachelor's Thesis, Life Science and Technology.


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HSP90, a major heat shock protein, plays a role in stabilization and activation of important proteins in tumors, such as the pro-survival factor Akt and oncogenic proteins like ErbB2 and BCR-ABL. Tumor cells can go in apoptosis when those proteins are degraded or not able to function properly. Therefore, inhibiting HSP90, causing degradation of those proteins, can result in apoptosis of tumor cells. However, the question is how this works and if this works in patients. Even though HSP90 inhibition did already show some promising results in clinical trials, it is necessary to consider the importance of tumor selectivity and toxicity. HSP90 inhibitors seem to specifically target tumor cells, due to the tumor cell ‘addiction’ to HSP90. Nonetheless, not all tumors respond to HSP90 inhibition and some tumors are able to use other pathways to evade the inhibition of HSP90. Specifically, tumors dependent on one specific oncoprotein that is completely dependent on HSP90 do respond to HSP90 inhibition. Therefore, screening of tumors for these characteristics is crucial for predicting a response to this treatment and so is crucial for further development of HSP90 inhibitors.

Item Type: Thesis (Bachelor's Thesis)
Supervisor name: Kampinga, H.H.
Degree programme: Life Science and Technology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 16 Apr 2018
Last Modified: 02 May 2018 11:46

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