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HSP-70 & HSP-90: role in neurodegenerative diseases and potential as therapeutic targets.

Prats Lujan, Alejandro (2018) HSP-70 & HSP-90: role in neurodegenerative diseases and potential as therapeutic targets. Master's Thesis / Essay, Molecular Biology and Biotechnology (2016-2019).

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Neurodegenerative diseases have been increasing for the past decades, and will continue their rise in the incoming years. This manifests the importance to develop effective therapies. Despite their differences, all diseases have in common the protein aggregation and dysregulation of the Proteostasis. One of the main regulators in protein homeostasis are the heat-shock proteins (HSP), assisting the protein folding as chaperones. Within this group of molecules, HSP-70 and HSP-90 have become a target for many therapeutic approaches by inhibition or induction of their activity. Additional therapies have targeted other molecules involved in their regulation such as the transcription factor HSF-1 or histone deacetylates (HDAC), and others have focused in repairing mutated genes or delivering molecules with chaperone properties. Many of these therapeutic approaches have shown promising results and entered their final steps of the clinical trials. On the other hand, other approaches also showed promising applications, but failed to deliver the expectations or encountered toxicity and safety problems.Many advances have been done in the past years, but many issues remain unsolved. Heat-shock proteins, and specially HSP-70 and HSP-90 families have proved to be an interesting target for therapeutic techniques, with further alternatives arising from the development of new and better techniques.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Bergink, S.
Degree programme: Molecular Biology and Biotechnology (2016-2019)
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 19 Jun 2018
Last Modified: 20 Jun 2018 12:04

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