Wabeke, Ronja (2018) Synaptic pruning in Alzheimer’s disease in a classic complement- and microglia dependent manner. Research Project 2 (major thesis), Behavioural and Cognitive Neurosciences.
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Abstract
Synaptic pruning is one of the most important hallmarks of Alzheimer’s disease (AD). Synaptic pruning during development is initiated by the complement system and microglia. In genome wide association studies microglia and complement where identified in AD. To find out, among other things, if the synaptic pruning in AD works comparable to the synaptic pruning in development, this review will address the question: what is the relation between the classical complement system and microglia, in synaptic pruning in AD. It was found that the classical complement has an important role in the pruning of synapses in AD and that the underlying mechanisms are comparable to the synaptic pruning in development. The complement system tags the synapses, microglia recognize these tags and phagocytosis is followed. Inhibiting the complement system could prevent synaptic pruning in AD. C1q, a protein of the complement system, is suggested to be a possible target in AD therapy.
| Item Type: | Thesis (Research Project 2 (major thesis)) |
|---|---|
| Supervisor name: | Eisel, U.L.M. |
| Degree programme: | Behavioural and Cognitive Neurosciences |
| Thesis type: | Research Project 2 (major thesis) |
| Language: | English |
| Date Deposited: | 10 Jul 2018 |
| Last Modified: | 13 Jul 2018 07:19 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/17763 |
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