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The Immunophenotype of Mast Cells. The search for Diagnostic & Prognostic Features within Systemic Mastocytosis.

Alheraky, Abdulrazzaq (2018) The Immunophenotype of Mast Cells. The search for Diagnostic & Prognostic Features within Systemic Mastocytosis. Research Project, Pharmacy.

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Systemic mastocytosis is a clonal disorder that is defined by the neoplastic proliferation of MCs in one or more organ systems where the cKIT D816V activating point mutation plays a predominant role. Constitutive activity of the KIT receptor, excessive proliferation, increased cell survival and an aberrant expression of a series of proteins is induced. The WHO 2017 classification of SM is clinically subdivided into different forms; ie. indolent systemic mastocytosis (ISM), smouldering systemic mastocytosis (SSM), aggressive systemic mastocytosis (ASM), systemic mastocytosis with an associated hematological neoplasm (SM-AHN) and mast cell leukemia (MCL). In some cases ISM disease progression to ASM or MCL occurs. The immunophenotype of MCs aids in the determination of the diagnose of SM. Signalizing specific patterns in the immunophenotype of MCs that associate with the development of an indolent form of SM to a non-indolent form of SM or an AHN could be of great prognostic value. In this research the aim is to discover SM subtypes on immunophenotypical grounds and to detect associations between immunophenotype and clinical features of added value. In this study, a series of immunophenotypical patterns within SM versus non-SM cases have been characterized. For this, a flow cytometric gating strategy has been developed. A frame of parameters consisting of clinical features with implications for clinical treatment and decision making is set. It is of importance that the data for this frame is collected, and coupled to the immunophenotypical database. Thereby extrapolating our immunophenotypical findings to the clinical setting, and thus finding associations that may help considering time and choice of therapy.

Item Type: Thesis (Research Project)
Supervisor name: Dijck-Brouwer, D.A.J.
Degree programme: Pharmacy
Thesis type: Research Project
Language: English
Date Deposited: 13 Dec 2018
Last Modified: 18 Dec 2018 15:23

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