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RNA interference and antiviral defense

Inklaar, Maartje (2019) RNA interference and antiviral defense. Master's Thesis / Essay, Molecular Biology and Biotechnology (2016-2019).


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One of the intracellular defense mechanisms against viral intruders is the production of virus-derived small silencing RNAs, that guide specific virus clearance by RNA interference (RNAi). This antiviral response by RNAi has been shown in plants, fungi and animals. Though, there is continuous debate about the antiviral function of small silencing RNA in mammals. Consistent with such an antiviral response in mammals are the reported virus-encoded suppressors of RNAi. Not only antiviral RNAi response in mammals is researched to a large extent, but also PIWI-interacting RNA (piRNA) and their associated PIWI clade of Argonaute proteins are subject of many studies. PiRNA has a main function in genome defense, by silencing transposons, but there is also an increasing amount of reports of piRNA and a role in antiviral defense. This review will summarize the current knowledge regarding small silencing RNAs and their biogenesis mechanisms. Furthermore, I will discuss recent finding concerning antiviral RNAi defense and piRNA is highlighted throughout the review.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Haastert, P.J.M. van
Degree programme: Molecular Biology and Biotechnology (2016-2019)
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 11 Jan 2019
Last Modified: 14 Jan 2019 11:32

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