NK Cell Immunotherapy for Acute Myeloid Leukemia

Strating, Inge (2019) NK Cell Immunotherapy for Acute Myeloid Leukemia. Bachelor's Thesis, Biology.

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Abstract

Acute myeloid leukemia (AML) is an aggressive hematological disease, characterized by an increasing incidence by age and high mortality. The standard treatment of AML is chemotherapy, possibly followed by a hematopoietic stem cell transplantation (HSCT) for patients with a high risk of recurrence.The high relapse rate is a major problem in AML. This is mainly due to residual AML cells that remain in the body after chemotherapy. Therefore, it is necessary to develop a therapy that also attacks these residual AML cells and thus improves the overall survival in AML patients. Immunotherapy has been of great interest in the past years for therapeutic strategies in various cancers. Recent advances with chimeric antigen receptor (CAR) T-cells for other hematological malignancies have generated interest for this method in AML patients, but also early results for natural killer (NK) cell therapy are promising for the treatment of AML. NK cells are cells of the innate immunity, although they also have been described to play a role in adaptive immunity. NK cells are in possession of strong cytolytic responses and have the ability to release mediators, such as cytokines and chemokines that mediate inflammatory responses. They control cancer cells by interacting with them or enhancing the function of other (immune) cells in the tumor environment. Many studies have been performed about priming allogeneic NK cells to activate them and with the idea of administering these activated cells to AML patients and induce anti-tumor responses in this way. Even clinical trials have already shown promising results for this strategy. In this review, the possibilities of NK cells in immunotherapeutic strategies against AML blasts will be discussed.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Schuringa, J.J.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	23 Jul 2019
Last Modified:	23 Jul 2019 11:47
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/20391

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