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Current techniques and future directions of liver fibrosis imaging

Kloosterman, Rianne (2019) Current techniques and future directions of liver fibrosis imaging. Master's Thesis / Essay, Medical Pharmaceutical Sciences.


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Chronic liver disease is responsible for over 2 million deaths every year, with half of those deaths being caused by cirrhosis. Liver fibrosis is characterized by excessive collagen production and extracellular matrix (ECM) deposition, and can have a wide variety of causes. Fibrosis is divided into five stages, depending on the fibrotic state. Accurate diagnosis and staging are key in the prognosis and monitoring of the disease progression. The current golden standard for the diagnosis and staging of liver fibrosis is a biopsy. However, due to its invasive nature and the risks involved, there is a need for a non-invasive fibrosis imaging technique. Ultrasound (US) and magnetic resonance imaging (MRI) are imaging techniques currently used in the clinic, but have limited accuracy, especially in the earlier stages of fibrosis. US-based transient elastography (TE) has shown potential for the diagnosis and staging of early stages of liver fibrosis, but lacks in accuracy. MRI-based magnetic resonance elastography (MRE) has shown greater potential, as it can diagnose and stage liver fibrosis with high accuracy, even the earlier stages of liver fibrosis. The focus of this essay is to determine which imaging technique is the best for the diagnosis and staging of liver fibrosis, and whether it can be applied for theranostics

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Poelstra, K.
Degree programme: Medical Pharmaceutical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 01 Nov 2019
Last Modified: 04 Nov 2019 10:02

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