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The 936-group lactococcal phage

Giesbers, Conradus (2019) The 936-group lactococcal phage. Master's Thesis / Essay, Molecular Biology and Biotechnology (2016-2019).

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Since the discovery of bacteriophages in 1917, phages were already used to fight bacterial infections. Decades later phage research was at the center of understanding genes function, was instrumental in the rise of molecular biology, and a promising tools to fight antibiotic resistant bacteria. The amount of phages is immense, with about 1031 phage particles in the biosphere. Almost all phages have dsDNA genomes and tails. While phages have been very beneficial, in the dairy industry, phages cause big problems by infecting the milk fermenting Lactic acid bacteria (LAB). When this occurs the whole process has to be restarted, yielding big economic damages. Therefore, much research has been done into lactococcal phages. The most common phage group, isolated from different places all over the world, is the so called 936-group phage. This phage group is not only the most common, but also has advantages over other lactococcal phage groups. The 936 phages are more heat resistant, can increase its virulence, easily overcomes host-receptor changes, and can persist for a long time in the same location. Furthermore, many bacterial systems that prevent phage infection are active against the 936 phages. In this assay phages, their evolution, application, characteristic and phage-host interaction are discussed. Lactococcal phages, specifically the 936 phages and the advantages they have, from a phage and host point of view are discussed.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Haastert, P.J.M. van and Kortholt, A.
Degree programme: Molecular Biology and Biotechnology (2016-2019)
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 27 Nov 2019
Last Modified: 28 Nov 2019 10:18

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