Bos, Jasper (2019) Catalytic sites on self- replicating fibres. Master's Thesis / Essay, Chemistry.
|
Text
Thesis_Final_JasperBos.pdf Download (20MB) | Preview |
|
![[img]](https://fse.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
toestemming.pdf Restricted to Registered users only Download (163kB) |
Abstract
Creating life de-novo is one of the largest challenges that science is facing at the moment. It requires a system in which the characteristics of life are incorporated. Three such characteristics are essential for any living system: replication, metabolism and compartmentalisation. At the basis of metabolism lies the property that a system should be able to facilitate chemical transformations. Recently the group of Sijbren Otto discovered a peptide based self-replicator capable of catalysing both the retro-aldol reaction and Fmoc deprotection reaction, an emergent property of the system. In this thesis we designed several replicator building blocks aimed at perturbing the active sites of this self-replicating system. Using several different techniques the properties of these self-replicators were investigated. After briefly investigating if the set of reactions catalysed could be expanded, the activity of the new replicators in the existing reactions was tested. The work further focusses on linking the discovered properties of the replicators to their activity as a catalyst. Mixing building blocks is utilised in order to further perturb the active sites in the system and the effects of this are studied.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Otto, S. |
| Degree programme: | Chemistry |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 02 Dec 2019 |
| Last Modified: | 05 Dec 2019 10:52 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/21270 |
Actions (login required)
 |
View Item |