The microbiome and late-onset neonatal sepsis

Geerlings, Lotte (2020) The microbiome and late-onset neonatal sepsis. Bachelor's Thesis, Biology.

Preview	Text The microbiome and late-onset neonatal sepsis.pdf Download (743kB) | Preview
	Text toestemming.pdf Restricted to Registered users only Download (129kB)

Abstract

Neonatal sepsis is a systemic infection and is one of the leading causes of mortality and morbidity in prematurely born infants worldwide. Neonates which contract sepsis within three days post-partum are diagnosed with early-onset neonatal sepsis, and after diagnosed with late-onset neonatal sepsis. The prevalence of late-onset sepsis is increasing, and survivors are at risk of developing multiple life-threatening conditions. One factor that can protect the baby is the gut microbiome, which is a critical arbiter in maintaining host health. Imbalanced gut microbiota in neonates can play a factor in the pathogenesis of late-onset sepsis. Because of this imbalanced state, often called dysbiosis, supplementation of probiotics to the neonatal gut microbiota has been thoroughly inspected. Causality of neonatal dysbiosis in relation to late-onset sepsis has been established in a mouse model by translocation of Klebsiella pneumoniae from the neonatal dysbiotic microbiome to the liver. Second, the bacteria most commonly responsible for sepsis can be found in the neonatal gut mucous layer, as opposed to only the skin which was thought previously. Moreover, preterm neonates have a far lower viscosity of the mucous in the epithelial layer of the gut, resulting in an increased permeability of the epithelial layer. Neonatal dysbiosis is directly linked to that of maternal dysbiosis and preterm birth.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Harmsen, H.J.M.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	28 Feb 2020 11:42
Last Modified:	28 Feb 2020 11:42
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/21608

Actions (login required)

View Item