Stem cell transplantation as a treatment for acute myeloid leukemia

Koopmans, J (2020) Stem cell transplantation as a treatment for acute myeloid leukemia. Bachelor's Thesis, Biology.

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Abstract

Acute myeloid leukemia is the most common type of acute leukemia found among the elderly. After an induction treatment with chemotherapy to reach a remission of the leukemia, hematopoietic stem cell transplantation is seen as the number one treatment to possibly cure the leukemia. Several studies showed that for these stem cell transplantations, the use of younger stem cells is preferred over the use of older ones. This post-remission treatment, however, is not used for every patient, since not every patient reaches a complete remission and for some patients the induction therapy will be too heavy. Treating the older patients with a transplantation was for a longer time not desirable, but since the important introduction of the reducedintensity conditioning it was also possible to treat the elderly. Two out of three studies showed promising results, in which no difference in overall-survival and progressionfree survival was seen between the younger and older patients receiving a hematopoietic stem cell transplantation. When a patient is in need for stem cells, but no matching donor can be found, unmatched stem cells from the umbilical blood seems to be a promising alternative for stem cells from bone marrow or peripheral blood, since these stem cells can be easily stored and are directly available.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Haan, G. de
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	12 May 2020 09:32
Last Modified:	12 May 2020 09:32
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/21866

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