de Jong, Esmee (2020) The influence of Toxoplasma (T.) Gondii on the brain and behaviour. Master's Thesis / Essay, Biomedical Sciences.
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Bachelor thesis,The influence of Toxoplasma (T.) Gondii on the brain and behaviour.pdf Download (453kB) | Preview |
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Abstract
The protozoan parasite Toxoplasma gondii (T. gondii) is a single cell eukaryote that uses its host cells to survive. In order to survive it has three stages of life, tachyzoites, bradyzoites or sporozoites, with the goal to end up in definite feline hosts. Hosts are protected by initiate and secondary immunity against the parasite; however immune cells can get invaded by T. gondii where they are used to enter organs and the BBB. When the parasite is manifested in the host it can cause behavioral changes, in rodents specifically it can lead to fatal attraction towards the definite host. In psychiatric diseases such as Alzheimer's, Parkinson's and Schizophrenia but also depression and suicidal behavior in humans and T. gondii also seems to be of influence. Hard definite conclusions about the involvement of T. gondii in behavioral changes can and psychiatric diseases are hard to make because of the many possible factors found and how poorly their underlying mechanisms are understood.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Havekes, R. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 04 Jun 2020 11:06 |
| Last Modified: | 04 Jun 2020 11:06 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/21999 |
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