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Skin cancer associated with using thiazides in hypertensive patients

Naasan, Moustafa (2020) Skin cancer associated with using thiazides in hypertensive patients. Master's Thesis / Essay, Medical Pharmaceutical Sciences.

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Abstract

Purpose: This study investigated the association between using thiazides diuretics in hypertensive patients and the potential risk of several types of skin cancer including non-melanoma skin cancer (NMSC), basal cell carcinoma (BCC), squamous cell carcinoma (SCC), merkel cell carcinoma (MCC), Lip cancer, malignant melanoma and malignant adnexal skin tumors (MAST). Methods: All records found regarding the correlation between thiazide diuretcis and skin cancer were collected and scanned from our data source PubMed after applying inclusion and exclusion criteria. Results: Pedersen et al reported adjusted odd ratios for merkel cell carcinoma (MCC) and malignant adnexal skin tumors (MAST) correlated with high use (≥50,000 mg) of hydrochlorothiazide were 2.3 and 3.6, respectively. These results increased to 3.3 for MCC and 5.6 for MAST when higher doses were applied (≥100,000 mg). Pottegard et al has found that thiazide diuretics was associated with an increased risk of squamous cell carcinoma (SCC), [adjusted odds ratio (aOR), 1.86; 95% confidence interval (CI), 1.23–2.80] and slightly increased risk of basal cell carcinoma (BCC) (aOR,1.19; 95% CI, 1.02–1.38). Kreutz et reported in their 6 studies [two studies suggested increased risk of malignant melanoma by (17% and 32%)], [two studies suggested increased risk of squamous cell carcinoma by (58% and 75%)] and [two studies suggested increased risk of lip cancer by (110% and 119%). Mayne and Colleagues reported that 95% of lip canc

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Hak, E. and Wilffert, B.
Degree programme: Medical Pharmaceutical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 09 Jun 2020 09:58
Last Modified: 09 Jun 2020 09:58
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/22043

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