Bosch, Sarianne (2020) Pre-clinical research models for regenerative therapies in Diabetes Mellitus type one. Bachelor's Thesis, Life Science and Technology.
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Abstract
In Diabetes Mellitus type 1, the yet incurable variant, patients are unable to overcome auto-immune nature of the disease. Donor islet transplantation was a breakthrough in the treatment of these patients, but has proven to be far from optimal. Therefore, regenerative models are currently exploited for their utility as new diabetes therapies. In this thesis, three regenerative research models on Diabetes type 1 are reviewed and compared. All three models show the capability of developing insulin-producing cells in vitro and in vivo in mice. Pluripotent stem cell models allow patient-derived cells to develop into functional beta-cells, but their safety in vivo is questionable. Organoids are superior to stem cell models regarding cell maturation, cell-matrix interactions and genomic stability. However, similar to stem cell models, in vivo acceptance of the graft is not guaranteed, since immune reactions towards implanted cells are highly likeable to appear. A third model is the bio-artificial pancreas, designed to escape an immune-attack towards insulin-producing cells. This improvement makes the bio-artificial pancreas the most promising model. However, inadequate insulin production of cultured cells, cell vascularization and the human immune-reaction towards (encapsulated) cells remain recurrent problems in all three research models. With these problems solved, the discussed regenerative therapies could improve the quality of life in Diabetes type 1 patients significantly.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Coppes, R.P. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 11 Jun 2020 11:59 |
| Last Modified: | 11 Jun 2020 11:59 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/22048 |
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