Brongers, Pieter (2020) Thermodynamic model for the partitioning of self-replicator building blocks in complex coacervates. Bachelor's Thesis, Chemistry.
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Abstract
Two essential properties that contributed to the origins of life and are necessary for the synthesis of life de novo are compartmentalization and self-replication. Recently a self-replicating system has been combined with complex coacervates and strong partitioning is observed. This study presents a model based on statistical thermodynamics to be able to describe this behaviour. The general principles are presented before being applied to partitioning of the replicator building block. This showed that the available space in coacervates is much lower than is expected based on its volume. It also allows to determine the free energy of partitioning. The discussion is extended to include macrocycles and linear oligomers. Only small energetic gains of a few kT for a macrocycle in a coacervate compared to in the solvent phase can cause major amplification in the prevalence of rings of size five and larger. The model also includes saturation effects showing that this causes larger species to become more prevalent.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Otto, S. and Blokhuis, A.W.P. and Kiani, A. |
| Degree programme: | Chemistry |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 03 Jul 2020 11:01 |
| Last Modified: | 03 Jul 2020 11:01 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/22392 |
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