Sex dimorphic effects in calorie restriction and CR mimetics on longevity

Baas, Sigrid (2020) Sex dimorphic effects in calorie restriction and CR mimetics on longevity. Bachelor's Thesis, Biology.

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Abstract

The ageing population is an increasing problem worldwide. Calorie restriction (CR) is seen as a promising intervention that prevents age-associated diseases and extends longevity in most animal models studied so far. CR is defined as the reduction of energy intake without malnutrition. And obstacle is that the precise calorie intake for the optimal outcome is hard to determine, as this is influenced by a lot of factors. With therapeutic intervention it is possible to activate the same pathways, but without the adverse effects. There have been multiple reports of sex-dimorphic effects in response to CR and CR mimetics. More research is needed to identify these effects to utilize CR to its full potential. In this report the sex-dimorphic effects on calorie restriction as a longevity intervention will be explored. In the main findings this will be done by discussing the nutrient sensing pathways known to be affected by CR. There are some pathways that not only play a role in nutrient sensing, but also adjust cellular processes. After this the connections between the pathways and their regulation by CR are explained. The connections between the pathways are proven to be important in the response to CR. Finally, the drug based longevity interventions and their sex-dimorphism are discussed. It has been concluded that there are a lot of reports about sex-dimorphism in response to CR and CR mimetics, but there is a great need for more extensive research on the subject.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Muller, C. and Calkhoven, C.F.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	07 Jul 2020 07:22
Last Modified:	07 Jul 2020 07:22
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/22482

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