How miR34-a could be used as a therapeutic against cancer

Kuiper, Jildau (2020) How miR34-a could be used as a therapeutic against cancer. Bachelor's Thesis, Life Science and Technology.

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Abstract

Cancer is still a huge problem in the world and although many different medicine exists the perfect treatment remains to be found. Nowadays, microRNAs (miRNAs) are thought to be used as a new kind of medicine to counteract cancer. MiRNAs have shown to play an important role in various cell processes by binding to their respective complementary mRNA sequence and in this way block the translation of the mRNAs into proteins. In many diseases, including cancer, it was found that the miRNAs were dysregulated. In cancer one particularly miRNA was often found to be downregulated, this is miRNA-34a (miR-34a). The mRNA targets of miR-34a are often involved in the stimulation of cell proliferation and if these are not properly regulated, it will result in uncontrolled cell growth. Since miR-34a is involved in the downregulation of these proteins the thought occurred that miR-34a mimics could possibly work as a therapeutic. This drug was already going through medical tests phase I, but was terminated due to the fact that some patients had a severe immune reaction during the protocol. However, more miRNAs are going through test phases and with the use of the right transport systems they could possibly evolve to a good medicine against cancer. Maybe have the power to eradicate cancer from the world completely. In my thesis I show how miR-34a is involved in cell processes,what role it plays in the development of cancer and how it can be used as a therapeutic against cancer.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Kok, J.
Degree programme:	Life Science and Technology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	27 Jul 2020 13:14
Last Modified:	27 Jul 2020 13:14
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/22876

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